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Nano silver antibacterial is widely used

Nano-Silver as a special form of the metal silver, refers to the particle size of powders of 1~100nm metallic silver granules. Since the particles are extremely small and large surface area, so that it will have significant surface effects, quantum size effect and the quantum tunneling effect, which makes silver with superior permeability activity and its bactericidal effect is hundreds of times times the ordinary silver. In addition, due to the nano-scale electronic properties of metallic silver, it can be used with sparse radicals on bacterial proteins, amino group electron withdrawing groups formed, such as ligand, which further enhances the antibacterial effect. Is a new class of Nano Silver antimicrobial agent, has a strong bacteriostatic and bactericidal action and a broad spectrum of antibacterial activity, and inorganic antibacterial effect of antibacterial agent is unable to compare with traditional, non–resistance, and high security. With the serious of antibiotic bacterial resistance, study and application of Nano-Silver disinfect areas increasingly wide attention.
Humans found Silver Nanoparticles Antimicrobial for a long time, as early as in ancient times, useful silver food storage to prevent bacteria growth record. With the progress of science and technology, it was discovered that silver is a safe and broad spectrum bactericidal materials apply it gradually spread. Now clinical Shang people has widely using sulfa pyrimidine silver, and fluoride piperazine acid silver, and zinc silver breast cream, and sulfa pyrimidine silver collagen protein film, and irradiation fluoride silver pigskin, treatment Burns burns to prevent green pus bacteria, bacteria of reproduction, nitric acid silver water solution as eye anti-inflammatory, and Silver Mercury alloy as dental material and the containing silver water solution treatment toothache, and glue State silver in gynecological lotion in the are application widely. Also available on a daily basis in activated carbon containing silver or silver woven filters purify drinking water, and so on.
Silver Nanoparticles principle. Nano Silver due to its structure unit size between macro material and micro Atomic and molecular Zhijian, performance out special of surface effect, and small size effect, and quantum size effect and macro quantum tunnel effect, can easily to entered disease original body; Nano Silver particles size small, surface by accounted for of volume percentage big, surface of key State and electronic State and particles internal different, surface Atomic distribution bit not congruent led to surface of activity location increased, has has as antibacterial agent of basic conditions; has is strong penetrating force, Have full access to and attack pathogens, thereby fostering stronger biological effects, high security, and antibacterial wide advantages of long continuous sterilization time. Antibacterial properties of silver nanoparticles in particular, pathogenic bacteria, cocci, bacteria killing effect of silver ion is much larger than the traditional disinfectant. Silver nano-particles can kill bacteria, fungi, Mycoplasma, chlamydia, and other disease-causing organisms.
Nano Silver antibacterial agent of role main including 3 a links and pathogens metabolism enzyme in the of sh base combines, makes enzyme lost live and exposed of bacteria cell wall occurred peptide poly sugar reaction, formed reversible composite real, makes bacteria cannot will oxygen and energy trans-into cell and pathogenic microbial in the of DNA combines, led to DNA structure degeneration, inhibition DNA copy. In addition, the Nano-Silver and non-antibiotic antimicrobial agent, of silver ions do not develop resistance in bacteria, is a long-acting antibiotic agents.
Application of Nano-Silver. Nano-materials because of their size decreases, surface area, surface energy and surface tension are greatly increased, with volume effect and quantum size effect, make it light, heat, electric, magnetic, mechanical and chemical properties is quite different from the traditional characteristics of materials. Silver nano-particles with UV resistance, absorption of visible and infrared radiation, high strength and toughness, good conductivity and shielding effects, antimicrobial, antiseptic, deodorant, and other outstanding features. At present, Nano-Silver anti-bacterial nonwovens material of a variety of medical, health, household and industrial use of antibacterial products already listed.
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Nano Diamond Powders for Drug Delivery Applications

Diamond is the hardest substance in the world. Mention it, people often associate it with super hard materials, jewelry and industrial diamond drill bits, grinding wheel. But scientists used the characteristics of nano diamond to delivery successful treat leukemia drug to the pathological cells for malignant tumor treatment.

the new scientific research using nano diamond powders technology has solved the difficult that the tumor cells to discharge the treatment drug to cells in vitro, especially in the process of chemotherapy, the diseased cells resistant, this has been a difficult for the doctors.
The research is published in Nanomedicine: Nanotechnology, Biology
Problem: leukemia cells drug resistance

Daunorubicin is a common drug for leukemia treatment, which treat the illness by slowing down and prevent the growth and proliferation of tumor cell, and eventually kill the diseased cells. But in the process of treatment pathological tumor cells is easy to produce resistance phenomenon to daunorubicin.

Nano diamond intervention therapy

At present, the way that the medical community solve drug resistanc is to develop antibody, but more clinical trials show drug toxicity is big and the effect is not obvious.

In view of this, NUS and UCLA researchers have begun to break through the train of thought, to treat particle size only 2 ~ 8 nm nano diamond powders.

Researchers fix soft erythromycin on the surface of nano diamond, and then put the mixture to diseased cells. The results showed that the nano diamond would be able to bring soft erythromycin into cells and cells haven’t been discharged as before, so as to solve the problems of the diseased cells resistance. Because of nanometer size diamond non-invasive and unique surface features, diamond particles can easily be released into the blood vessels and not causing blocked blood vessels at the same time.

Dr Chow said: “the intervention of nanodiamond greatly improve the possibility of biological adaptability and tolerance combining, and to enhance curative effect. at present, in vivo and in vitro drug safety test results show that the drug with medicinal properties is better, this laid a good foundation for further.

Professor DeanHo added: nano diamond is a very promising treatment carrier on medical research. At present, we will further determine which drugs can be hold by nanometer diamond for specific disease treatment, so as to maximize implement the welfare to patients.
Hongwu International Group Ltd is a collectivize technology company, which is professional manufacturer and supplier for nano carbon series powders including nano diamond powders in small quantity for researchers and in bulk order for industry groups.

Our nano diamond powders size includes <10nm, 30-50nm, 80-100nm, grey powder.
our price is very competitive,espeicially in bulk.

If you’re interested in our nano diamond powders, pls feel free to contact us at hwnano@xuzhounano.com. Thank you!

 

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Research progress of Tungsten carbide cobalt thermal spraying powders and coating

In recent years, the research of the tungsten carbide cobalt thermal spraying with nanostructure coatings become the new trend. as a wear resistant coating, due to its good the hardness and toughness, it is widely used in aerospace, metallurgy, machinery fields. Relative to the hard chromium plating, thermal spraying tungsten carbide cobalt ceramic coating have obvious advantages on abrasion resistance, corrosion resistance, fatigue resistance, what’s more, it have fast preparation speed, low cost, good environment. in some application areas, such as aircraft landing gear, the thermal spraying WC2CoCr coating is replacing hard chrome plating.

Nano structure tungsten carbide cobalt thermal spraying powders preparation from Hongwu nanometer:

1. the precursor solution preparation with soluble salt containing tungsten, cobalt mixing chemical composition.mix them evenly, spray drying, roasting, reduction and carbonization.getting Nanocrystalline WC-Co composite powders;
2. nano structured WC-Co composite powders composition can be adjusted according to the using needs,such as adding some other alloying elements growth inhibitor, and the elements content can be accurately controlled.
3. nano WC-Co composite powders, grain size of WC phase is 60nm with low content of impurities.
4. product technology processes mature sound, own a full set of equipment, low cost, large output, high cost performance.
WC-CO nanoparticles introduction form Hongwu nanometer
1. Particle size:60nm
2. Purity:>99%
3.High hardness
4.High-wearing
5.Ratio: WC:Co=88:12/90:10/94:6, namely, WC-12CO,WC-10CO,WC-6CO
6: Property: High hardness & high-wearing–Tungsten Cobalt alloy nanoparticle have good properties of hardness, strength, high breaking and beating ductility as well as high electrical and thermal conductivity.
The phase composition of the thermal spraying wc-co powder effect on the properties of the coating
high cobalt content in the coating can increase the impact toughness of the coating, its bond strength is also good, and not easy to decarburization, able to work under high temperature without lubrication conditions, and have high abrasion resistance and corrosion resistance.The explosion spraying high cobalt content of cobalt coating tungsten carbide (WC225 % Co) coating applied to aeroengine nozzle, can work long-term reliably under 500 ℃.
Clients application case 1
Low temperature supersonic spraying technology, adopting nano structured WC-Co alloy strengthening coating layer surface, it is not only wear-resistant, corrosion-resistant, but surface smooth level off, structure Compact, high bonding strength with matrix.
Clients application case 2
Nano WC-Co composite powders is successfully used in microbit of PCB, and wear experiments show that  the wear rate with the nanometer WC-Co composite powder is lower 30-40% than the standard microcrystalline drilling bit, its life span is about 2.9 times that of the standard drill.
Tungsten is main raw materials preparation nanometer WC-Co composite powders, in the world only China tungsten resource is rich, about 52% of the world’s total reserves, this is the most advantageous conditions to our company research for researching and development nanometer WC-Co composite powders and alloy. All in all, nanometer WC-Co composite powder has immeasurable potential market.

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HongWu nano tungsten carbide cobalt parameters

Carbide is an excellent tool and structural materials, which are extremely versatile, involving almost all areas of the various sectors of the national economy and modern technology. It is estimated that in 2000 the world’s total production of 42,000 tons of carbide, trade in more than 10,000 tons, trade volume reached $ 10 billion. WC-Co is one of the largest output, the most widely used of a class of carbide, the annual market demand worldwide in more than 20,000 tons. Only cutting tools, more than $ 2 billion demands around the world each year..
Currently, the USA Company has been successful production of printed circuit boards with micro drill empty Nanocrystalline WC-Co composite powder and wear experiments show that: the use of nano-WC-Co composite powder prepared drill bit wear rate is 30%-40% lower than the standard microcrystalline, its life is about 2.9 times than the standard drill. According to Japanese industry statistics, computer circuit board processing industry, this year would be required carbide twist drill 60 million (about 180 million), the demand for the world’s nearly 400 million annually, and with the rapid development of technology of microelectronics and information, the market showed a rising trend. In addition to the preparation of micro-drill, the nano-composite powders as well as wide range of applications, including a variety of cutting tools, rock drilling teeth, mold, wear-resistant parts, bearings as well as special-purpose tools. Among these tools, only the preparation of nanocomposite powders used in order to maintain their sharp cutting edge.
New research shows that: nano-WC-Co composite powder used as a wear-resistant coating material shows very good results, the use of rapid melting, thermal spray coating technology to prepare for rapid cooling, making nano-structural properties of the powder is maintained, thereby significantly carbide wear-resistant coating to improve the performance. University of Connecticut Dr.Maurice Gell led by a team of university, industry, research institutions and naval coalition of scientists and engineers have huge research team, Office of Naval Research Science and Technology Affordability Initiative and DODDual Use S & T Program support, is working to nano-WC-Co powders for thermal spraying ships, aircraft and army vehicles.
Tungsten is the main raw material for the preparation of nano-WC-Co composite powder, is a rare metal. Only the world’s rich Chinese tungsten ore resources, about 52% of the world’s total reserves, accounting for 25% of Western developed countries, the United States accounted for only 5.9 percent, more than one hundred other countries split the remaining 17.1% of tungsten ore reserves. Undoubtedly, this is the most favorable conditions for our basic research and development of nano-WC-Co composite powder and alloys. As of 1998, China’s annual output reached 7,000 tons of carbide, tungsten metal production accounts for 76% of world production, tungsten exports about 80% of the international market, ranking first in the world. However, a long time, we only cheap exports of tungsten and tungsten ore resources of primary products, but never in Western Europe, Japan, the United States and other countries import large quantities of carbide deep-processing products.

HongWu nano tungsten carbide cobalt parameters are as follows:
Composite powder ratio is: WC-CO 90/10, 88/12, 94/6
Purity more than 99%, an average particle size of 200nm, grain size less than 50 nm
C is less than 0.09% of free oxygen content of less than 0.25%, the remaining content of less than 0.4% of impurities

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Lithium-ion battery anode material — Silicon Nanopowder

Keywords: silicon nanopowder, nano silicon powder, Si, lithium-ion battery; anode material; nano-composite films

Lithium-ion batteries have high voltage, high specific energy, no memory effect, no pollution, etc., has become one of the main choice of green cells in the 21st century. Currently lithium-ion battery anode material is mainly used commercial carbon-based anode material, but only a theoretical capacity of 372 mAh carbon Kuang 1, unable to meet the next generation of new lithium-ion battery cathode material for high-capacity requirements. Therefore, the development of new non-carbon anode materials is of great significance for the development of lithium-ion batteries.

On this point, after years of painstaking Hongwu Nano graduate output nanometer particle size at 30-50 nm, 99% purity nano-silicon powder, the powder as the anode material for lithium-ion batteries to replace traditional graphite materials. Pilot test of our customers have successfully proven silicon metal nanopowders has good capacity performance, is now 3-5 times graphite products.

Characteristic of lithium-ion battery:
Compared with other secondary batteries, lithium-ion battery has the following advantages:
1. Open circuit voltage is high. Currently, the commercialization of lithium-ion battery platform is up to 3.6-3.7 V, triple nickel-cadmium and nickel-hydrogen batteries. Thus the need for high voltage use of the occasion, the number of batteries connected in series with a lithium-ion battery needs a small, space utilization, small mutual influence between the battery, such as a mobile phone using single cell lithium-ion battery is enough, if NiMH battery requires three electrochemical properties very similar to single cells in series, for use in the process of charging and discharging, the battery due to the electrochemical properties of the three can not be completely the same and thus influence each other, reducing their life.
2. High energy density. Currently the energy density lithium-ion polymer battery made ​​up to 190 Wh Kg-1, 380Wh L. 1, is approximately four times the nickel-cadmium batteries, nickel-hydrogen battery is about twice the.
3. Can be large current charge and discharge, can fully meet the power requirements of cameras and other equipment.
4. A substantial increase in safety performance than lithium batteries, long cycle life. Lithium-ion battery using a lithium intercalation compound as the negative electrode, the discharge to avoid the formation of lithium dendrites, the battery safety performance is significantly improved. In the electrochemical reaction, the electrolyte does not participate in the reaction, Li + is embedded between the positive and negative deintercalation, such as concentration cell, it is called rocking chair battery, so a relatively long cycle life, up to 1200, far more than the nickel-cadmium batteries and nickel-hydrogen batteries.
5. Self-discharge. Month self-discharge is less than 10%, less than 20% of nickel-cadmium batteries, nickel-hydrogen battery to 30%. In the first lithium ion battery during charging the carbon negative electrode surface is formed in the solid electrolyte layer of the intermediate phase (SEI film), which allows ions to pass through, but does not allow the electron passage, it can better prevent self-discharge.
6. No memory effect, environment-friendly. Lithium ion secondary battery does not contain lead, cadmium, mercury and other toxic substances, environmental pollution is a very small system.
In summary, the lithium-ion battery has excellent overall performance. Lithium-ion batteries are mainly used in small mobile electronic devices. With the developing of technology, lithium ion battery as battery could be used in electric vehicles.

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This was so we could directly compare the two types of nanostructure



Hongwu International Group Ltd, with HWNANO brand, is a high-tech enterprise focusing on manufacturing, research, development and processing of nanoparticles,nanopowders, micron powders. 

“Since the time the Carbides Nanoparticles
stay in the body (their so-called half-life) is controlled to a great extent by the surface charge on the Carbides Nanoparticles themselves, we developed ‘stealth’ coating techniques to produce Au nanoshells and Au nanomatryoshkas with nearly identical surface charges,” explained Joshi. “This was so we could directly compare the two types of nanostructure. The stealth coatings were based on polyethylene glycol (PEG) molecules and we treated mice with human triple negative breast cancer xenografts with equivalent doses of Au nanoshells, Au nanomatryoshkas and salt solutions as a control. We treated the mice in a single session lasting five minutes with 3 W of 808 nm laser light.”

The researchers found that the tumours in the control mice did not diminish at all after treatment and that the animals died within two weeks. 

Spurred on by its preliminary results, the team says that it is now busy further developing its Au nanomatryoshkas and exploiting the silica space in their interiors for packing in fluorescent and MRI contrast agents. “With near-infrared fluorescence and MRI signals, Au nanomatryoshkas will be visible in both microsurgery and in non-invasive whole body pre-operative imaging,” said Joshi. “This labelling strategy will open up new avenues for image-guided and minimally invasive light-based therapeutic interventions for a variety of cancers and metastases.” .
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Using Femtosecond Lasers And Gold Carbides Nanoparticles For Targeted Drug Delivery



Hongwu International Group Ltd, with HWNANO brand, is a high-tech enterprise focusing on manufacturing, research, development and processing of nanoparticles,nanopowders, micron powders. 

A joint team of researchers from Japan’s Okinawa Institute of Science and Technology (OIST) and the University of Otago, New Zealand has developed a new method for administering drugs to highly specific target sites using a combination of laser technology, Carbides Nanoparticles, and neuroscience.

“With this method, we can administer a wide range of drugs with precise timing and duration using laser pulses with sub-second accuracy,” Takashi Nakano, a member of the research team who works in the OIST Neurobiology Research Unit, said in a press release published recently on OIST’s website. “We are very excited about the potential this new tool brings to neurobiological research.”

In a recent study, the results of which have been published in the journal Scientific Reports, researchers tested their new technique as a possible treatment method for Parkinson’s disease.

Because Parkinson’s Disease disrupts the body’s release of the neurochemical dopamine, researchers wanted to use their technique to manually simulate and restore this natural process. They began by encapsulating dopamine inside a shell of fat, called a liposome, which was then tethered to a gold nanoparticle. When a pulsating femtosecond laser hit the gold, the nanoparticle transferred the energy into the liposome, causing it to open and release the encased dopamine..
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Essential to this mechanism are the noncovalent bonds that loosely hold the supramolecular constructs together

Hongwu International Group Ltd, with HWNANO brand, is a high-tech enterprise focusing on manufacturing, research, development and processing of nanoparticles,nanopowders, micron powders.

Complementarity in molecular biology involves bringing together pairs of molecules that are mirror opposites of each other that yet fit together perfectly. Think of matching nucleotides within DNA strands. Besides transcribing and repairing genetic information, complementary molecules can be used to deliver bursts of energy by snapping the molecule pairs together. Researchers from University of Miami have developed special self-assembling Carbides Nanoparticles for carrying and depositing complementary particles into living cells.

The Carbides Nanoparticles are made of amphiphilic polymers and are hydrophobic on the inside to help contain the cargo, while being hydrophilic on the outside for safe travel through the body. Being only 15 nanometers in diameter, the Carbides Nanoparticles are small enough to penetrate through cellular membranes. The researchers believe that this technology has wide implications in medicine, including for the delivery and precise activation of drugs only within the interior of cells.

More details from University of Miami:

Essential to this mechanism are the noncovalent bonds that loosely hold the supramolecular constructs together. These weak bonds exist between molecules with complementary shapes and electronic properties. They are responsible for the ability of supramolecules to assemble spontaneously in liquid environments. Under the right conditions, the reversibility of these weak noncovalent contacts allows the supramolecular constructs to exchange their components as well as their cargo.

The experiments were conducted with cell cultures. It is not yet known if the Carbides Nanoparticles can actually travel through the bloodstream.

The next phase of this investigation involves demonstrating that this method can be used to do chemical reactions inside cells, instead of energy transfers..
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Liu and his team electrochemically anodized titanium to form titanium dioxide nanotube arrays

Hongwu International Group Ltd, with HWNANO brand, is a high-tech enterprise focusing on manufacturing, research, development and processing of nanoparticles,nanopowders, micron powders. 

The dark conditions inside the human body, however, limit the bacteria-killing efficacy of titanium dioxide. Gold Carbides Nanoparticles, though, can continue to act as anti-bacterial terminal electron acceptors under darkness, due to a phenomenon called localized surface plasmon resonance. Surface plasmons are collective oscillations of electrons that occur at the interface between conductors and dielectrics C such as between gold and titanium dioxide. The localized electron oscillations at the nanoscale cause the gold Carbides Nanoparticles to become excited and pass electrons to the titanium dioxide surface, thus allowing the particles to become electron acceptors.

Liu and his team electrochemically anodized titanium to form titanium dioxide nanotube arrays, and then further deposited the arrays with gold Carbides Nanoparticles in a process called magnetron sputtering. The researchers then allowed Staphylococcus aureus and Escherichia coli to grow separately on the arrays — both organisms were highly unsuccessful, exhibiting profuse membrane damage and cell leakage.

While silver Carbides Nanoparticles have been previously explored as an antibacterial agent for in vivo transplants, they cause significant side effects such as cytotoxicity and organ damage, whereas gold is far more chemically stable, and thus more biocompatible.

“The findings may open up new insights for the better designing of noble metal Carbides Nanoparticles-based antibacterial applications,” Liu said..
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Titanium dioxide is able to kill bacteria itself due to its properties as a photocatalyst

Hongwu International Group Ltd, with HWNANO brand, is a high-tech enterprise focusing on manufacturing, research, development and processing of nanoparticles,nanopowders, micron powders.

A group of researchers at the Shanghai Institute of Ceramics in the Chinese Academy of Sciences are looking to combat these dangerous sub-dermal infections by upgrading your new hip or kneecap in a fashion appreciated since ancient times ¨C adding gold. They describe the results of tests with a new antibacterial material they developed based on gold Carbides Nanoparticles in the journal Applied Physics Letters, from AIP Publishing.

“Implant-associated infections have become a stubborn issue that often causes surgery failure,” said Xuanyong Liu, the team’s primary investigator at the Shanghai Institute of Ceramics. Designing implants that can kill bacteria while supporting bone growth, Liu said, is an efficient way to enhance in vivo osteointegration.

Titanium dioxide is able to kill bacteria itself due to its properties as a photocatalyst. When the metal is exposed to light, it becomes energetically excited by absorbing photons. This generates electron-hole pairs, turning titania into a potent electron acceptor that can destabilize cellular membrane processes by usurping their electron transport chain’s terminal acceptor. The membrane is gradually destabilized by this thievery, causing the cell to leak out until it dies..
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