This was so we could directly compare the two types of nanostructure

Hongwu International Group Ltd, with HWNANO brand, is a high-tech enterprise focusing on manufacturing, research, development and processing of nanoparticles,nanopowders, micron powders. 

“Since the time the Carbides Nanoparticles
stay in the body (their so-called half-life) is controlled to a great extent by the surface charge on the Carbides Nanoparticles themselves, we developed ‘stealth’ coating techniques to produce Au nanoshells and Au nanomatryoshkas with nearly identical surface charges,” explained Joshi. “This was so we could directly compare the two types of nanostructure. The stealth coatings were based on polyethylene glycol (PEG) molecules and we treated mice with human triple negative breast cancer xenografts with equivalent doses of Au nanoshells, Au nanomatryoshkas and salt solutions as a control. We treated the mice in a single session lasting five minutes with 3 W of 808 nm laser light.”

The researchers found that the tumours in the control mice did not diminish at all after treatment and that the animals died within two weeks. 

Spurred on by its preliminary results, the team says that it is now busy further developing its Au nanomatryoshkas and exploiting the silica space in their interiors for packing in fluorescent and MRI contrast agents. “With near-infrared fluorescence and MRI signals, Au nanomatryoshkas will be visible in both microsurgery and in non-invasive whole body pre-operative imaging,” said Joshi. “This labelling strategy will open up new avenues for image-guided and minimally invasive light-based therapeutic interventions for a variety of cancers and metastases.” .
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