Nano Diamond Powders for Drug Delivery Applications

Diamond is the hardest substance in the world. Mention it, people often associate it with super hard materials, jewelry and industrial diamond drill bits, grinding wheel. But scientists used the characteristics of nano diamond to delivery successful treat leukemia drug to the pathological cells for malignant tumor treatment.

the new scientific research using nano diamond powders technology has solved the difficult that the tumor cells to discharge the treatment drug to cells in vitro, especially in the process of chemotherapy, the diseased cells resistant, this has been a difficult for the doctors. The research is published in Nanomedicine: Nanotechnology, Biology.

Problem: leukemia cells drug resistance

Daunorubicin is a common drug for leukemia treatment, which treat the illness by slowing down and prevent the growth and proliferation of tumor cell, and eventually kill the diseased cells. But in the process of treatment pathological tumor cells is easy to produce resistance phenomenon to daunorubicin.

Nano diamond intervention therapy

At present, the way that the medical community solve drug resistanc is to develop antibody, but more clinical trials show drug toxicity is big and the effect is not obvious.

In view of this, NUS and UCLA researchers have begun to break through the train of thought, to treat particle size only 2 ~ 8 nm nano diamond powders.

Researchers fix soft erythromycin on the surface of nano diamond, and then put the mixture to diseased cells. The results showed that the nano diamond would be able to bring soft erythromycin into cells and cells haven't been discharged as before, so as to solve the problems of the diseased cells resistance. Because of nanometer size diamond non-invasive and unique surface features, diamond particles can easily be released into the blood vessels and not causing blocked blood vessels at the same time.

Dr Chow said: "the intervention of nanodiamond greatly improve the possibility of biological adaptability and tolerance combining, and to enhance curative effect. at present, in vivo and in vitro drug safety test results show that the drug with medicinal properties is better, this laid a good foundation for further.

Professor DeanHo added: nano diamond is a very promising treatment carrier on medical research. At present, we will further determine which drugs can be hold by nanometer diamond for specific disease treatment, so as to maximize implement the welfare to patients.

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